Slight (1)modafinil will increase the stage or effect of pantoprazole by affecting hepatic enzyme CYP2C19 metabolism. Minimal/Importance Mysterious. Net effect on pantoprazole steps mysterious due to opposing outcomes of CYP450 enzymes; watch
Belzutifan is usually a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors might raise incidence or severity of adverse outcomes. Check for anemia and hypoxia and reduce belzutifan dose as proposed.
On the other hand, even supposing 4 studies have documented related conclusions, the total variety of investigate topics continues to be Considerably much too little to come to any good conclusions about modafinil’s opportunity for medically managing schizophrenia — and also a lot additional exploration will likely be necessary to examine this additional.
Steer clear of or substitute An additional drug for these prescription drugs when achievable. Evaluate for loss of therapeutic result if medication have to be coadministered.
modafinil will reduce the level or effect of copyright topical by influencing hepatic enzyme CYP2B6 metabolism. Insignificant/Importance Not known.
Keep track of Closely (one)voriconazole will boost the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
modafinil will increase the stage or result of clobazam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Dosage adjustment could possibly be essential; CYP2C19 inhibitors might lead to greater exposure to N-desmethylclobazam (active metabolite).
It can be unfamiliar if the consequences of the medicine will be increased by using caffeine. Caffeine is on the market in several foods, beverages, and remedies. Question your health practitioner if you need to Restrict or alter your ingestion of caffeine-containing products although on this medication.
Medicine that have limitations aside from prior authorization, quantity limits, and move therapy associated with Every prescription.
modafinil will lessen the level or influence of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Reasonable CYP3A4 inducers may perhaps decrease progestin concentration; think about use of further barrier procedures
modafinil will decrease the extent or impact of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Warfarin's significantly less potent R-enantiomer click here is metabolized in part by CYP3A4 (and likewise CYP1A2 and CYP2C19). Check INR extra often if coadministered with inhibitors of these isoenzymes and alter warfarin dose if required.
Keep away from other unsafe actions until finally you know how modafinil will have an effect on your level of wakefulness.
Ensure you understand how you respond to this medication before you decide to push, use machines, or do other Employment that call for you to be warn, well-coordinated, or ready to Believe or see nicely.